BIRC6 and Familial prostate cancer: Moreover, plenty of evidence indicated that BIRC6 was overexpressed in a variety of cancers including glioma, childhood de novo acute myeloid leukemia, breast cancer, neuroblastoma, prostate cancer and non-small-cell lung cancer, and overexpression of BIRC6 was correlated with carcinogenesis, progression and poor prognosis of malignant tumor[12,16,18,33,34,35].