Therefore, we aimed to investigate whether AMPK plays an active role in regulating hepatic cholesterol metabolism by modulating SREBP-2 and whether AMPK affects the TSH-induced up-regulation of SREBP-2 in the liver; these data may provide a basis for the future clinical treatment of hypercholesterolemia associated with TSH. Here, PRKAA1 is linked to familial hypercholesterolemia.