Sterile protection against P. falciparum malaria can efficiently and reproducibly be achieved in the Controlled Human Malaria Infection (CHMI) setting by repeated inoculation of live sporozoites by bites of laboratory-reared Anopheles mosquitoes to healthy malaria-naïve volunteers under chemoprophylaxis: ChemoProphylaxis and Sporozoites (CPS-) immunization [2,3]. This evidence concerns the gene CAD and malaria.