IGHE and allergic disease: Allergic diseases are skewed towards a Th2 phenotype and classic Th1 (such as C57Bl/6 and SJL/J) and Th2-prone (such as Balb/c and A/J) strains were characterized as high (Balb/c, A/J), intermediate (C57Bl/6), and low (SJL/J) IgE responders based on in vivo IgE production post immunization [7].