As shown in Fig 5a, when the NPs siRNA TMPRSS2-ERG-SQ were injected by i. v. in SCID mice, tumour growth was strikingly inhibited (70%, p<0.001) compared to mice treated with NPs siRNA Control-SQ, non-vectorized siRNA TMPRSS2-ERG IV or saline solution. This evidence concerns the gene TMPRSS2 and neoplasm.