A statistically significant decrease in invasiveness was found in the case of breast cancer cells with MMP3 expression silenced, in comparison to the control cells, at the 10th, 15th, and 20th hours of the experiment (p<0.0001, p<0.0001 and p<0.0001, respectively; Bonferroni multiple comparison test) (Fig 7C). The gene discussed is MMP3; the disease is breast carcinoma.