Because there has been small but fairly consistently observed increased rate of kidney disease in individuals genotyped as heterozygous for the G1 or G2 risk alleles (but much smaller than the risk for those with two copies of G1 or G2), we were interested in the possibility that a non-trivial subset of individuals with apparent G0G1 genotype may have a third copy of APOL1 due to this chromosomal rearrangement that could increase risk of disease. The gene discussed is APOL1; the disease is kidney disorder.