ENO2 and central nervous system cancer: We selected seven glycolytic genes (HK2, PFKP, ALDOA, PGAM1, ENO1, ENO2 and PDK1; Fig 1B) and confirmed their strong up-regulation under hypoxia by QPCR in seven GBM cell lines (five patient derived glioma stem-like cells and two adherent GBM cell lines; Fig 1C).