Mutations in 16 genes have been identified to be associated with classical ALS, including mutations in superoxide dismutase (SOD1), TARDBP, fused in sarcoma (FUS), UBQLN2, profiling, and C9ORF72, but these are rare (Ferraiuolo et al., 2011; Rademakers and Blitterswijk, 2012; Chen et al., 2013). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.