A recent paper examining the effect of SNO-PDI formation on α-synuclein aggregation and Lewy-like neurite formation, found that in addition to SNO-PDI formation activating α-synuclein aggregation, it was also seen to provoke co-localization and in parallel the formation of α-synuclein:synphilin-1-containing Lewy-body-like aggregates, supporting the role of SNO-PDI in PD pathogenesis (Kabiraj et al., 2014). The gene discussed is P4HB; the disease is Parkinson disease.