FLT3 and acute myeloid leukemia: Another FLT3 inhibitor that has demonstrated inhibitory activity against FLT3-ITD/N676D, FLT3-ITD/F691L, and FLT3-D835Y mutants is G-749, which displayed potent antileukemic activity in bone marrow blasts from AML patients regardless of FLT3 mutation status [115].