Finally, the GeparQuattro [20] was a prospective study that enrolled 1509 patients with locally advanced BC, from which 451 HER2-positive and 1058 HER2-negative, to receive epirubicin and cyclophosphamide (EC) and then be randomly assigned to either docetaxel, docetaxel plus capecitabine, or docetaxel followed by capecitabine. This evidence concerns the gene ERBB2 and breast cancer.