MYBPC3 and hypertrophic cardiomyopathy: For example, a 25 bp deletion in MYBPC3 associated with hypertrophic cardiomyopathy and a sevenfold increase in the risk of heart failure was discovered in South Asians, whereas it would have probably remained undetected if studies were confined to other ancestries (since this variant was nearly absent in the other 20 non-South Asian populations studied [33]).