CD4 and systemic lupus erythematosus: However, these histologic findings and clinical features including rash, fever, and lymphadenopathy are shared with systemic lupus erythematosus (SLE) and Kikuchi disease.26 Nevertheless, lupus patients could have different laboratory results including autoantibodies, hypocomplementemia, and leukopenia, and their cutaneous histopathologic findings reveal more dense inflammatory cell infiltration, mostly CD4-positive lymphocyte, and positive immunofluorescence results.