For ischemic stroke patients, these rt-PA–induced blood abnormalities may lead to recurrent stroke after thrombolysis due to endogenous tPA inhibition.26 In this context, it is not surprising to find studies revealing that statin discontinuation not only ended the beneficial antithrombus impact but also promoted microthrombolus reform as well as inhibited collateral circulation.27,28. Here, PLAT is linked to ischemic stroke.