Meanwhile, dexmedetomidine also inhibited the expression of TLR4 and MyD88 and the activation of ERK1/2 and NF-κB in the lung tissues of CLP-induced septic rats, indicating that the anti-inflammation effect of dexmedetomidine in sepsis maybe base on TLR4/MyD88/ERK1/2/NF-κB signal pathway. Here, MAPK3 is linked to Sepsis.