The Motesanib NSCLC Efficacy and Tolerability (MONET1) study, which assessed the effect of adding motesanib, a small-molecule targeted antagonist of VEGFR-1, 2 and 3, to doublet chemotherapy (carboplatin and paclitaxel) compared with chemotherapy alone for first-line therapy of non-squamous NSCLC, reported a significant improvement in tumour response rate (40% vs. 26%, respectively), but no benefit in overall survival (median 13 vs. 11 months, respectively) [47]. Here, FLT1 is linked to neoplasm.