The Aldh1a2 gene stands out to cardiac experts because it uniquely displays three features: it is co-regulated by both Tbx20 and Gata4, it is more than 16-fold up-regulated in the cardiac fibroblasts compared to tail fibroblasts, and its mutation is known to be highly associated with diverse congenital heart disease phenotypes, including Tetralogy of Fallot and Pentalogy of Cantrell [30,31]. This evidence concerns the gene ALDH1A2 and congenital heart disease.