The main finding of the present study is that COMT rs4818 polymorphism does not influence the susceptibility or clinical phenotype of MwoA, MwA or CM, even when considering migraine patients subsets, such as those characterized before or during the attack by symptoms due to pre- or post-synaptic dopamine receptor activation, such as yawning, vomiting and hypotension (dopaminergic migraineurs) [3] or those with pure menstrual or menstrually related migraine (hormonally modulated migraine, HMM [20]). The gene discussed is COMT; the disease is migraine disorder.