We thus compared with the same gene expressions (up-regulated transcripts: SLC16A4, DSC3, ALDOB, EPHX4, ARHGAP24; and down-regulated transcripts (MS4A12, TMIGD1, CASP5) in 5 colon cancer lines: HCT 116, Caco2, HT-29, Lovo, and C32. This evidence concerns the gene DSC3 and malignant colon neoplasm.