Ezrin, a link protein of cell membrane and cytoskeleton, can anchor actin in specific membrane, maintain cell polarity, take part in cell shape regulation and cell movement, interact with a variety of cell surface molecules (CD44, Met, etc.)[6], regulate cell-cell adhesion with cell-extracellular matrix, and promote metastasis and proliferation of tumor cells. The gene discussed is EZR; the disease is neoplasm.