Nematodes also express a unique family of monoamine-gated Cl- channels that appear to be highly conserved within the phylum, including the C. elegans 5-HT- and TA-gated Cl- channels, MOD-1 and LGC-55, that play key roles in 5-HT- and TA-dependent muscle paralysis, respectively. This evidence concerns the gene CBX1 and Paralysis.