A closer analysis of selected genes that are related to the leukemia phenotype and are deregulated upon siRNA-mediated AML1-ETO depletion [24,30] (please see below) further confirms an AML1-ETO/N-CoR dominant co-occupancy pattern that may regulate the leukemic phenotype at the genome-wide level (Figure 1D). The gene discussed is RUNX1; the disease is leukemia.