The Kidney Disease: Improving Global Outcomes (KDIGO) anemia work group suggests a trial of i.v. iron for all adult anemic patients with CKD and iron deficiency (defined as serum ferritin ≤500 μg/L and transferrin saturation [TSAT] ≤30%) but states that in patients with ND-CKD, a trial of oral iron (1–3 months) can be used as an alternative [5]. The gene discussed is TF; the disease is chronic kidney disease.