ZC3H12A and Cerebral ischemia: Another study showed that the LPS stimulation in MCPIP1-deficient mice significantly increased the volume of cerebral infarction, accompanied by a significant upregulation of the pro-inflammatory cytokines in ischemic brain tissue, indicating that the protective effect of LPS preconditioning against cerebral ischemia was generated through the reduced level of pro-inflammatory cytokines by MCPIP1 [79].