Additionally, clinical studies have also shown that the expression of TLR3 or TLR9 in the peripheral blood of patients with ischemic stroke did not correlate with the neurologic impairment [41], which further suggests that TLR3 and TLR9 are not directly involved in the regulation of inflammatory injury of cerebral ischemic reperfusion (I/R). This evidence concerns the gene TLR3 and ischemic stroke.