The putative GD and HT susceptibility genes include both immune modifying genes HLA Class II gene [3,4], cytotoxic T lymphocyte-associated factor 4 (CTLA-4) gene [5,6], CD40 gene [5-7], protein tyrosine phosphatase-22 (PTPN22) gene [5], and other thyroid-specific genes for the thyroid stimulating hormone receptor (TSHR) [5,8] and thyroglobulin (TG) [9], as well as the novel proinflammatory cytokine such as interleukin-17 (IL-17) [10] and IL-21 [11]. The gene discussed is TG; the disease is hematocrit.