After adjustment for fibrinogen (F = 20.9, df = 1, P < 0.0001), HbA1c (F = 11.2, df = 1, P = 0.001), T2DM duration (F = 8.4, df = 1, P = 0.004) and insulin therapy (F = 1.8, df = 1, P = 0.18), glucose concentration significantly influenced clot permeability (F = 6.6, df = 2, P = 0.002). The gene discussed is INS; the disease is type 2 diabetes mellitus.