There was a significant J-shape relationship betwen fasting bood glucose versus Ks (β0 = 4.96, p < 0.001; β1 = 0.61, p = 0.002; β2 = −0.04, p = 0.002) and t50 (β0 = 12.0, p < 0.001; β1 = −0.64, p = 0.008; β2 = 0.04, p = 0.007) in T2DM patients treated without insulin (Figure 4A) but not on insulin (Figure 4B). This evidence concerns the gene INS and type 2 diabetes mellitus.