For instance, Urhammer et al. [30] showed that the UCP1 polymorphism was not associated with obesity in a Danish population, and Pihlajamaki et al. [31] reported that BMI and serum biochemistry were not significantly different based on UCP1 genotype in Finnish subjects with family combined hyperlipidemia. Here, UCP1 is linked to obesity due to melanocortin 4 receptor deficiency.