For example, the increased levels of estrogens, insulin and insulin-like growth factor 1 (IGF 1) [10,22], as well as changes in the immune response and adipokines expression [12,23], which lead to a pro-inflammatory state, triggering DNA damage and angiogenesis that could result in increased tumor cell survival, proliferation, invasion and metastasis [10]. The gene discussed is INS; the disease is neoplasm.