TFPI and coronary artery disorder: Given the minor risk allele A of rs6903956 has been suggested to confer a decreased C6orf105 mRNA expression in CAD patients [16], it is possible that genetic variant of C6orf105 hence affect TFPI expression by altering ADTRP, resulting in endothelial cell dysfunction and abnormality of coagulation, which might explain rs6903956 contribute to CAD susceptibility.