Nevertheless, the two other SNPs (rs12504628 and rs13118928) at the HHIP locus associated with risk of COPD in subjects of 1992 in the follow-up population, were previously shown to be associated with lung function and risk of developing COPD in Caucasians [19,22,27] and rs12504628 in Chinese Han population [28]. The gene discussed is HHIP; the disease is chronic obstructive pulmonary disease.