Two SNPs (rs12504628 and rs13118928) at the HHIP locus and 1SNP (rs7671167) at FAM13A, which were chosen from those associated with an increased risk of COPD or lung function previously reported in Caucasians [19-22,27], were also associated with an increased risk of COPD in cross-sectional individuals, in 1992. This evidence concerns the gene HHIP and chronic obstructive pulmonary disease.