Among the 4SNPs in HHIP and 1SNP in FAM13A, which were demonstrated as being related to COPD susceptibility, the genotypes of rs7654947 in HHIP and rs7671167 in FAM13A in FEV1 decline were significantly different in cases or controls of the follow-up cohort. Here, FAM13A is linked to chronic obstructive pulmonary disease.