The lack of difference in parasitemia and hematocrit that we observed in HIV+ and HIV- subjects in the present study may be due to the high median CD4+ T-cell count of 484 cells/μL in the HIV+ group, which presumably represents only a modest reduction in immune competency and is associated with less risk for recurrent malaria compared to individuals with lower CD4+ T cell counts [2, 34]. Here, CD4 is linked to malaria.