Previousstudies have demonstrated that the pro-inflammatory cytokines tumor necrosis factoralpha (TNF-α) and interleukin-1 beta (IL–1β) regulateargininosuccinate synthetase 1 (ASS1) in cancer cell lines6.However, the biological effect of ASS1 on gastric carcinogenesis/metastasis remainslargely unclear. The gene discussed is ASS1; the disease is cancer.