In addition, the level of ASS1 expressionin gastric cancer cell lines affects cell motility following arginine withdrawal.Finally, the ASS1 protein promotes the metastatic abilities of tumor cells inexperimental models of gastric cancer metastasis in vivo. In conclusion, ASS1is overexpressed in gastric cancer, and the suppression of its expression inhibitstumor migration and metastasis in vitro and in vivo. This evidence concerns the gene ASS1 and neoplasm.