For confirmation, we quantified other genes frequently altered in AML, including TET2, IDH1, IDH2, DNMT3A, ASXL1, EZH-2, MLL, RUNX, CBFB and TCF3 [33], but we observed no consistent activation or repression of any of these genes in KD cells (Additional file 8: Figure S5). Here, KMT2A is linked to acute myeloid leukemia.