ESR1 and cancer: Notably, Insulin Receptor Signaling (6 genes), Actin Cytoskeleton Signaling (7 genes), ERK5 Signaling (4 genes), Phospholipase C Signaling (7 genes) and Estrogen Receptor Signaling (5 genes) were the five most enriched pathways (Fisher’s exact test p-value ≤ 0.05), while the top scoring disease-related pathway was that one relative to Cancer (145 genes).