As shown above at the mRNA level, the NFAT5 protein positivity was significantly different between IBC and nIBC independently of the tumor grade: in the grade 1–2 samples (14 IBCs and 56 nIBCs), NFAT5 staining was positive in 9 IBCs (64%) and in 10 nIBCs (18%; p-value = 4.7 10-4, χ2 test), and in the grade 3 samples (22 IBCs and 14 nIBCs), NFAT5 staining was positive in 16 IBCs (73%) and in 2 nIBCs (14%; p-value = 6.3 10-4, χ2 test). The gene discussed is NFAT5; the disease is neoplasm.