Therefore, in the present study, we examined PTB patients, LTBI subjects, and healthy controls (HC) from the Han population in Shanghai to test the association between 16 single-nucleotide polymorphisms (SNPs) of TLR1, TLR2, TLR4, TLR6, and TLR9 and TB, to determine the possible association of these polymorphisms with disease susceptibility. This evidence concerns the gene TLR4 and tuberculosis.