Therefore, in the present study, we examined PTB patients, LTBI subjects, and healthy controls (HC) from the Han population in Shanghai to test the association between 16 single-nucleotide polymorphisms (SNPs) of TLR1, TLR2, TLR4, TLR6, and TLR9 and TB, to determine the possible association of these polymorphisms with disease susceptibility. The gene discussed is TLR9; the disease is tuberculosis.