To explore the molecular mechanism through which BANCR led to the inhibition of cell proliferation and promotion of apoptosis of colorectal cancer, we analyzed BANCR over-expression and p21 mRNA or protein in sw480 and HCT116 cells, and we found that the expression of p21 mRNA did not change significantly, but p21 protein levels were significantly increased in the treated group compared with the control group. Here, BANCR is linked to colorectal cancer.