Together, these studies indicate that EIAV infection of ELR1/eCT1 mice can result in pathological organ changes similar to those observed in infected horses; the results show that EIAV can replicate in mMDMs from ELR1/eCT1 mice, suggesting the potential application of ELR1/eCT1 mice as a small laboratory animal model for EIA. The gene discussed is FGFR2; the disease is infection.