After treatment with picroside II, pERK1/2 expression was decreased, and both cell apoptosis and the damage to the ultrastructures of the neurons and BBB were reduced including the number of Mi increased and relative area of condensed chromosome and basement (BM) thickness descreased; thus, the cerebral infarct volume was diminished, and the mNSS scores were reduced. This evidence concerns the gene MITF and brain infarction.