Recent studies in low-density lipoprotein receptor–deficient mice, which are hyperglycemic but exhibit no marked dyslipidemia when compared with nondiabetic controls, showed that diabetes in the absence of diabetes-induced hyperlipidemia is associated with the accelerated formation of atherosclerotic lesions, similar to what is seen in fat-fed nondiabetic mice [30]. The gene discussed is VLDLR; the disease is metabolic syndrome.