Seizures induce neurogenesis in rodents [32], and animal models have shown electroconvulsive seizures to have effects on neurotransmitters, gene expression, growth factors (such as Brain derived neurotrophic factor - BDNF, Vascular endothelial growth factor - VEGF, Fibroblast Growth Factor - FGF) and neuropeptides (such as neuropeptide Y - NPY, Thyrotropin-releasing hormone - TRH, VGF) and lead to synaptic remodeling and cellular proliferation (reviewed in [33]). Here, TRH is linked to Seizure.