Gill’s study of 81,302 patients coded with dementia, who had syncopal events, found a similar probability of pacemaker insertion (0.3% each) but significantly higher pacemaker insertion rates in patients exposed to cholinesterase inhibitors (4.7 vs. 3.3 events per 1000-person years, HR 1.49; 95% CI, 1.12-2.00) [13]. The gene discussed is BCHE; the disease is dementia.