SP1 and systemic lupus erythematosus: miR-29b, which is upregulated in SLE CD4+ T-cells, has been shown to inhibit SP1 expression in human T-cells, meaning that they inhibit the expression of DNMT1 and modulate DNA methylation [74], and further studies demonstrated that inhibition of miR-29b in the T-cells of SLE patients reversed DNA hypomethylation and the upregulation of downstream genes.