In SLE, it was reported that anti-Su autoantibodies, which were usually found in lupus patients, could recognize the catalytic enzyme in miRNA pathways (Ago1, Ago2, Ago3, Ago4 and Dicer) [31,32], which indicated the possible mutual relationship between miRNA and the pathogenesis of SLE. This evidence concerns the gene AGO2 and systemic lupus erythematosus.