CREM and systemic lupus erythematosus: In addition to the transcription regulators, such as CREM (cAMP-responsive element modulator), CREB1 (CREM-binding protein 1) and NFAT (NFκB, AP1 and nuclear factor of activated T-cells), it was shown that miR-31, downregulated in SLE T-cells, could repress the expression of RhoA, a negative regulator of NFAT, and was responsible for impaired IL2 expression [79,80].