IFNA1 and systemic lupus erythematosus: Recent studies demonstrated that depletion of pDCs in BXSB/MpJ lupus-prone mice (males of this mouse model has mutant Yaa containing Y chromosome and develops severe form of SLE) ameliorated lupus pathology, which indicated that pDCs played critical roles during the IFN-dependent initiation of lupus and might be an attractive therapeutic target for treating SLE [62].