AFG3L2 and spinocerebellar ataxia type 28: AFG3L2 encodes for a subunit of the hetero-oligomeric m-AAA protease (ATPases associated with various cellular activities), a component of the mitochondrial ATP-dependent metalloprotease located on the inner mitochondrial membrane, and its mutations in heterozygosis are associated with Spinocerebellar ataxia type 28 (SCA28) [8].