We queried both cases and controls regarding PSA and DRE screening for PrCa; 98% of PrCa patients reported having had a serum PSA or digital rectal exam (DRE) before their cancer diagnosis, and the median diagnostic PSA was 72.9 ng/ml and 70% of patients has a PSA > 20 ng/ml. This evidence concerns the gene KLK3 and cancer.