IGF1 and irritable bowel syndrome: IPA analysis of the differentially expressed genes in IBD following the RR-MBI revealed significant enrichment for cellular growth and proliferation (e.g., ERK5 Signaling, ERK/MAPK, RhoA, Integrin, P53, Cdc42, and Actin-cytoskeleton signaling), inflammation and stress response (e.g., IGF1 and glucocorticoid receptor signaling, and NRF2-mediated oxidative stress response), as well as insulin-signaling related pathways (Fig 7C).