Activation of 4-OHT-dependent c-MycERTAM in the beta-cell compartment of pancreatic islets of the MycERTAM;Bcl-xL model of pancreatic neuroendocrine tumors (PNET) results in synchronous onset and progression of beta-cell proliferation, culminating in highly angiogenic and invasive tumors [26, 28]. This evidence concerns the gene BCL2L1 and pancreatic neuroendocrine tumor.