However, locomotor measurements carried out on post-stroke day7 (psd7) demonstrated that shh iKO mice showed significantly more severe motor deficits compared to wt littermates both in total distance travelled and total movement number measured in 24-hour period (total distance traveled = 87.9±14.6% of pre-stroke level for wt mice and 48.9±6.3% of pre-stroke level for shh iKO mice, p = 0.020, Student’s t-test; Total movement number = 67.7±6.8% of pre-stroke level in wt and 50.0±8.5% in shh iKO mice, p = 0.014, Student’s t-test, Fig 6III n = 7–8). Here, SHH is linked to Stroke.