EGF and hepatocellular carcinoma: Furthermore, according to chronic liver disease status in Asian controls, a significant association between EGF +61A/G polymorphism and HCC risk was obtained in patients with chronic liver diseases (G vs. A: OR = 1.165, P = 0.017, 95% CI: 1.028-1.321, I2 = 23.3%, Pheterogeneity = 0.266), and in healthy controls (G vs. A: OR = 1.142, P = 0.043, 95% CI: 1.004-1.299, I2 = 4.2%, Pheterogeneity = 0.383) (Table 2).