In an Australian population-based cohort, Mouchawar et al. found that 2/52 (4%) of very-early-onset (≤30 years) breast cancer patients who were unselected for family history carried a germline TP53 mutation, and 3/42 (7%) of early-onset (31 to 39 years) breast cancer patients with a family history of breast or ovarian cancer carried a TP53 germline mutation [7]. Here, TP53 is linked to breast carcinoma.