HIF-1α stabilizing agents increase the bactericidal capacity of phagocytic cells and epithelial cells [24,25,28,29], show therapeutic benefit in mouse models of Staphylococcus aureus skin infection [28,29], reduce intestinal tract inflammation and bacterial translocation in murine chemically-induced colitis [30], and support host defense during early stages of mycobacterial infection in zebrafish [31]. The gene discussed is HIF1A; the disease is colitis.