HIF1A and bacterial infectious disease: Mice with targeted deletion of HIF-1α in myeloid cells (neutrophils and macrophages) and skin or corneal keratinocytes are more susceptible to bacterial infection, with diminished antimicrobial peptide (AMP) and nitric oxide (NO) production and impaired microbicidal capacity demonstrable in the corresponding HIF-1α-deficient cells [23–25].