When WT and iNOS +/- mice were treated with AKB-4924 prior to UPEC CFT073 infection, we found that lacking a fully functional host iNOS system, the protective effect of AKB-4924 was significantly diminished; moreover, the effect of AKB-4924 was abolished in iNOS +/- mice (Fig 6D). The gene discussed is NOS2; the disease is infection.